Issue
After importing DNA sequences from Ensembl, some regions are uppercase and some are lowercase
Environment
Molecular Biology application - All systems and versions
Cause
Ensembl, the online genomic database, represents bases in repeat regions of the gene with lower-case letters. This is called soft-masking. It is an aesthetic choice they made to denote repeat regions of a gene.
Resolution Steps
To change the capitalization:
- Highlight the section or entire sequence.
- Right-click the highlighted section or sequence, then select Change case.