What is Benchling Bioprocess?
Benchling Bioprocess is the only cloud-native solution that provides an end-to-end solution for modern, high-throughput process development. It helps development teams accelerate their path to critical milestones, while increasing operational efficiency and simplifying technology transfers into manufacturing. Highly-structured process data from Bioprocess, supported by an ISA88-compatible data model, feeds into data science and machine learning platforms, helping users gain new process insights.
Benchling Bioprocess provides customers with several exciting new capabilities, including a visual process designer, guided process execution, and pre-built instrument integrations, all with a modern, easy-to-use interface that promotes fast and accurate data collection.
Benchling Bioprocess allows teams to harness their data at scale by ensuring that their data is structured and accessible within Benchling so that they can plan experiments more efficiently, reduce the time required for technology transfer, and power their machine learning and data science programs.
For more introductory information about Benchling Bioprocess, check out the Bioprocess Data Sheet or request a demo.
What does Benchling Bioprocess Support?
Benchling Bioprocess supports the entire spectrum of process development activities including:
- Recipe Design – users can design and modify their processes using an intuitive, visual recipe designer that allows them to sequence the order of unit operations, connect material inputs and outputs, and define process parameters
- Experiment Planning – users can apply the Recipes they’ve created to flexibly design experiments with variations across parameters and materials
- Batch Execution – users can execute their experiments with guided operator instructions that are dynamically populated from the Recipe and experiment plan, along with fields for structured and automated data capture
- Data Visualization – users can visualize data with full experimental context and traceability within the platform or move their structured data directly into 3rd party analysis tools or AI/ML pipelines.
Terminology and Relationships
In Bioprocess, a Study allows users to plan and execute Experiments. Each Experiment correlates to a single Recipe. Recipes are made up of one or more Unit Operations. Definitions and Step Groups can be configured within each Unit Operation which further define operator actions. For a visual explanation of these relationships, see the image below.
When users create a Study from a Recipe, they will define one or more conditions and one or more replicates for the run. Conditions refers to the number of sets of distinct parameter deviations from the norm. Replicates allow users to execute a run for a given condition one or more times. For a diagram of the relationships between Conditions, Replicates, and Studies, see the image below.
The hierarchy for Benchling Bioprocess is Recipe > Study > Experiment > Unit Operation > Step.
Terminology
Study: A Study contains all of the data and entities associated with a given experiment. Benchling Bioprocess uses a Process Development (PD) Study, as opposed to a custom Study. A PD Study can be used to execute an experiment and collect data for a given iteration of a Recipe. When you create a PD Study, you will plan an Experiment to define one or more conditions and one or more replicates for each condition for the Experiment.
Recipe: Recipes are created inside a Template Collection and are used as the template for executing an Experiment within a Study.
Unit Operation: An umbrella term for the full set of variables that can be configured within a Unit Operation of a Recipe. One or more Unit Operations sit within a Recipe. Each Unit Operation allows users to configure Definitions and Step Groups.
Condition: The specific variations in process parameters used in an experiment. Conditions allow users to execute an experiment with adjustments to the parameters in one or more of the unit operations that are defined in the Recipe. Replicates allow users to execute a given condition one or more times.
Definition: A comprehensive term encompassing all configurable aspects of a unit operation within a recipe. These include parameters, material inputs, material outputs, and equipment.
Material: Defines the input and output components involved in a unit operation.
Replicate: Multiple iterations of an experiment under the same conditions to ensure reliability.
Worksheet: The mini notebook entries that are created from a Recipe when a Study is executed are collated into a Worksheet. Each Worksheet has a subsection for each Step across all Step Groups that correspond to a given Unit Operation. One Worksheet is created per Unit Operation per Condition per Replicate. If, for example, you have a Recipe with 3 Unit Operations and you use it to design a Study with 4 conditions and 2 replicates, then 24 Worksheets will be created.
Frequently Asked Questions (FAQs)
Will Bioprocess have a full set of APIs?
Yes, Bioprocess will feature comprehensive APIs that align with Benchling's standard offerings across its platforms. Specific release dates will be announced as per the product roadmap.
Does Bioprocess require a separate tenant or re-implementation for existing Benchling users?
No, Bioprocess can be used within the same tenant as other Benchling applications, ensuring that PD teams and research teams can operate seamlessly under a unified platform.
How does Bioprocess handle extensive real-time data, like pH and dissolved oxygen measurements?
While Bioprocess is not designed as an instrument control system, it efficiently manages data uploads either directly or via files for subsequent visualization and analysis. We recommend maintaining your existing control systems for real-time measurements and integrating them with Benchling for data management.